Structure of PDB 8jsm Chain A Binding Site BS01

Receptor Information
>8jsm Chain A (length=1362) Species: 1570291 (Ebola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QHTQYPDARLSSPIVLDQCDLVTRACGLYSSYSLNPQLRNCKLPKHIYRL
KYDVTVTKFLSDVPVATLPIDFIVPILLKALSGNGFCPVEPRCQQFLDEI
IKYTMQDALFLKYYLKNVGAQEDCVDDHFQEKILSSIQGNEFLHQMFFWY
DLAILTRRGRLNRGNSRSTWFVHDDLIDILGYGDYVFWKIPISLLPLNTQ
GIPHAAMDWYQTSVFKEAVQGHTHIVSVSTADVLIMCKDLITCRFNTTLI
SKIAEVEDPVCSDYPNFKIVSMLYQSGDYLLSILGSDGYKIIKFLEPLCL
AKIQLCSKYTERKGRFLTQMHLAVNHTLEEITEIRALKPSQAHKIREFHR
TLIRLEMTPQQLCELFSIQKHWGHPVLHSETAIQKVKKHATVLKALRPIV
IFETYCVFKYSIAKHYFDSQGSWYSVTSDRNLTPGLNSYIKRNQFPPLPM
IKELLWEFYHLDHPPLFSTKIISDLSIFIKDRATAVERTCWDAVFEPNVL
GYNPPHKFSTKRVPEQFLEQENFSIENVLSYAQKLEYLLPQYRNFSFSLK
EKELNVGRTFGKLPYPTRNVQTLCEALLADGLAKAFPSNMMVVTEREQKE
SLLHQASWHATVRGSSFVTDLEKYNLAFRYEFTAPFIEYCNRCYGVKNVF
NWMHYTIPQCYMHVSDYYNPPHNLTLENRNNPPEGPSSYRGHMGGIEGLQ
QKLWTSISCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLETDADEQE
QSAEDNAARVAASLAKVTSACGIFLKPDETFVHSGFIYFGKKQYLNGVQL
PQSLKTATRMAPLSDAIFDDLQGTLASIGTAFERSISETRHIFPCRITAA
FHTFFSVRILQYHHLGFNKGFDLGQLTLGKPLDFGTISLALAVPQVLGGL
SFLNPEKCFYRNLGDPVTSGLFQLKTYLRMIEMDDLFLPLIAKNPGNCTA
IDFVLNPSGLNVPGSQDLTSFLRQIVRRTITLSAKNKLINTLFHASADFE
DEMVCKWLLSSTPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKII
NNNTETPVLDRLRKITLQRWSLWFSYLDHCDNILAEALTQITCTVDLAQI
LREYSWAHILEGRPLIGATLPCMIEQFKVVWLKPYEQCPQCSNAKQPGGK
PFVSVAVKKHIVSAWPNASRISWTIGDGIPGQPAIKPKCPSAALREAIEL
ASRLTWVTQGSSNSDLLIKPFLEARVNLSVQEILQMTPSHYSGNIVHRYN
DQYSPHSFMANRMSNSATRLIVSTNTLGEFSDSNIIFQNVINYAVALFDI
KFRNTEATDIQYNRAHLHLTKCCTREVPAQYLTYTSTLDLDLTRYRENEL
IYDNNPLKGGLN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8jsm Molecular mechanism of de novo replication by the Ebola virus polymerase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S14 K48 H49 R166 R170 R485 N501 K510 F511 R515 F563 R571 Y679 G710 R1054 A1058
Binding residue
(residue number reindexed from 1)		S11 K45 H46 R163 R167 R482 N498 K507 F508 R512 F560 R568 Y667 G698 R1042 A1046
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jsm, PDBe:8jsm, PDBj:8jsm
PDBsum8jsm
PubMed37699521
UniProtA0A1C4HDB0

[Back to BioLiP]