Structure of PDB 8jsh Chain A Binding Site BS01

Receptor Information
>8jsh Chain A (length=167) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RINGEIRAQEVRLTGLEGEQLGIVSLREALEKAEEAGVDLVEISPNAEPP
VCRIMDYGKFLYEKSKSSKEQKKKQKVIQVKEIKFRPGTDEGDYQVKLRS
LIRFLEEGDKAKITLRFRGREMAHQQIGMEVLNRVKDDLQELAVVESFPT
KIEGRQMIMVLAPKKKQ
Ligand information
>8jsh Chain g (length=1074) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaa
cacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacga
guggcggacgggugaguaaugucugggaaacugccugauggagggggaua
acuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagg
gggaccuucgggccucuugccaucggaugugcccagaugggauuagcuag
uaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagag
gaugaccagccacacuggaacugagacacgguccagacuccuacgggagg
cagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugcc
gcguguaugaagaaggccuucggguuguaaaguacuuucagcggggagga
agggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagc
accggcuaacuccgugccagcagccgcgguaauacggagggugcaagcgu
uaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucag
augugaaauccccgggcucaaccugggaacugcaucugauacuggcaagc
uugagucucguagagggggguagaauuccagguguagcggugaaaugcgu
agagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacu
gacgcucaggugcgaaagcguggggagcaaacaggauuagauacccuggu
aguccacgccguaaacgaugucgacuuggagguugugcccuugaggcgug
gcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaa
gguuaaaacucaaaugaauugccuuguacacaccgcccgucacaccaugg
gaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuac
cacuuugugauucaugacuggggugaagucguaacaagguaaccguaggg
gaaccugcgguuggaucaccuccu
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<......<................>.....>..
>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....
.<.<<........>>.>......>>.>.....<<<....>>>....<<<<
<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..
<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>
>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>.
..>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>
>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<.....
...<<<.<<<<.......>>>>.>>>..........>>>>>....>>.<<
<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>
>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<
<<<.......<<<<<<.....>>>>>>.....>>>>>>..>>>>>>>>>>
...<<<<<<<<...<<<<<<<....<<<<<<.....<<<......>>>..
......>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>
...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>..
.>>>>>>>>..........<<<<<<.<<<<<<<....<<.....>>....
>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....
>>>>....>>>..)))).]<.........>.......<<...<<<<...<
.......<..........<<<<<<.<<<<..<<....>>.>>>>>>>>>>
........>........>...>>>>....>>..........<<<<.<<<.
...>>>.>>>>.............
Receptor-Ligand Complex Structure
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PDB8jsh Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		A49 G50 V51 D69 Y70 G71 K72 Y75 E76 K79 K82 E83 K85 K86 V90 I91 Q92 V93 K94 E95 I96 K97 R99 D103 E104 G105 D106 V109 K110 S113 F117 K125 R131
Binding residue
(residue number reindexed from 1)		A36 G37 V38 D56 Y57 G58 K59 Y62 E63 K66 K69 E70 K72 K73 V77 I78 Q79 V80 K81 E82 I83 K84 R86 D90 E91 G92 D93 V96 K97 S100 F104 K112 R118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jsh, PDBe:8jsh, PDBj:8jsh
PDBsum8jsh
PubMed38148682
UniProtC3T7P7

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