Structure of PDB 8jnr Chain A Binding Site BS01

Receptor Information
>8jnr Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQR
TGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEEN
TGHTFNSLLCNLYRNEKDSVCWHSDDEPSLGRSPIIASLSFGATRTFEMR
KKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREP
RVNLTFRTVYP
Ligand information
Receptor-Ligand Complex Structure
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PDB8jnr The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
Resolution3.66 Å
Binding residue
(original residue number in PDB)		R122 Y127 Y141 Y143 V188 C189 H191
Binding residue
(residue number reindexed from 1)		R54 Y59 Y73 Y75 V120 C121 H123
Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8jnr, PDBe:8jnr, PDBj:8jnr
PDBsum8jnr
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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