Structure of PDB 8jnk Chain A Binding Site BS01

Receptor Information
>8jnk Chain A (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQRT
GIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENT
GHTFNSLLCNLYRNEKDSVDWHSDDCPSLGRSPIIASLSFGATRTFEMRK
KPPPEVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRT
VYP
Ligand information
Receptor-Ligand Complex Structure
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PDB8jnk The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
Resolution2.69 Å
Binding residue
(original residue number in PDB)		R122 E123 I125 Y127 R131 Y141 Y143 S144 V188 D189 H191 D193 C195 K261 Y263
Binding residue
(residue number reindexed from 1)		R53 E54 I56 Y58 R62 Y72 Y74 S75 V119 D120 H122 D124 C126 K185 Y187
Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8jnk, PDBe:8jnk, PDBj:8jnk
PDBsum8jnk
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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