Structure of PDB 8jhz Chain A Binding Site BS01

Receptor Information
>8jhz Chain A (length=2615) Species: 1505 (Paraclostridium sordellii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLISKDELIKLAYSIKPREDEYKTILTNLDEYNKLVTINNKDKYLQLKKL
NDSIDIFINKYKKSSRNRALFNLKKDISKEVILIKNSNISPVEKNLHFVW
IGGEVSDTALEYINQWADINRDYNIRVWYDGEAFLVNTLKKAIVEHSTTD
TLQLFEEDIKNPQFDNMKFYKKRMEFIYERQNRFINYYKSEINKPIKPTI
DDIIKSHLVSEYNKNSESLELYRRTSFEKISNNNGVDIRNNNLFTEQELL
NIYNQELLDRENLAAASDLVRLLALKDFGGVYLDVDMLPGIQPDLFKTIS
RPSSIGVDSWEMIKLEAIMKYKKYIKNYTSKNFDKLDQQLKDDFQITLES
KSEKSEIFSKLGNLDVSDLEIKIAFALGSVINQALISKKGSYLTNLVIEQ
VKNRYKFLNQHLNPAIELGGNFSDTTKNFHDSLFNSATSENSMFLTKIAS
YLQVGFMPEARATISLSGPGAYSSAYYDFINLQDNTIEKTLNASDLMEFK
FPESNLSQFTEQEINSLWSFDQASAKYQFEKYVRDYTQESLSEDSELDFN
KNTVLDKNYLLNNKIPSNNVEETGSKNYVHYIIQLQGDDISYESACNLFS
KNPKNSVIIQRNMNESAKSYFLSDNGESISELNKYRIPQRLKNKEKIKVT
FIGHGKDEFNTSEFAKLSVDSLSNEISSFLDIMKLDISPKNVEINLLGCN
MFSYNVNVEETYPGKLLLNNIDKIISTLPNVNKDNITIGANQYEVRINNE
GRKELLDHSGQWLNKEEAIMNDLSSKEYIFFDSIENRPKAKSKNLIELAS
ISDNIKTLLLDTNIDPETKFILNNLKLNIESSIDNNIYYEKLEPVKNIIH
NSIDNLTNEFNLIENVSDELYELKKINNLDDNYLISFEDISKNDSTYTIR
FINKNSGESVHIQTEKEIFLKYGEHITQEINTIKNNIIIDVNGNLIGNIE
LEHAPQVNTLNAAFFIQSLIDYSNNKDVLNNLRTSVKVQLYAQLFSTGLN
TIYDSIQLVNLISNAINDAINVLPTLTEGVPILATILDGISLGAAIKELS
ETNDPLLKKELEAKVGIIAINMSLSLASMISTVIGVGSELAIFLLPIAGI
SAGIPSLVNNELILHDKATSVVNYFTHLSESKKYGPFKLEDDKILSPIDD
LVISEIDFNTDSIKLGTCDILSMEGGSGYTVTNDIDHFFSSPYINSNIPP
LSIYPVMNIQTTNLDFSKDLMMLPNAPSRLLWWETGAVPGLRSLETDGTR
LLDSIRDFYPGKFYWRFYAWFDFAITTLKPVYENTNIKIKLDKNTRNFIM
PTITTDVIRNNLSYSFTGSGGTYSLLLSSHPISTNINLSKDDLWIFNIDN
KVREISIQNGTIKKGNLVRNALSNLDINKNKLTIDNQIINFSGDVDNKYR
YIFLNCSLDDEISLMIEINLFAKSYNLILSGNKDYLISNLSTIINKINNL
GLNSKNISYNYTDEFNNKYFGVISKTNQKSIICYKKGSKNILELYNGNML
LFDSKDFIADDINIFMKDDINTITGKYYIDNNLDISVDFSISLISKNKVK
VNGLYLNEYGYASFLEFIKNSDGHHNTSNFINLFLDNIGFWKLFGFNNIE
FVIDKYFAITGKTDMGYIEFICDNNKNIDIYFGEWKTSSTKNTIFSGNGR
NLIVEPIYDINAGDNISTSIDFSYEYISGIDIYINKILIVPNLYTELVNI
NTDYSSNKYFPEIIVLNTDTFHDKVNINLDSSSLDYEWAIDGSDFILSRY
LEENNRKILQKIRIKDILSNTKSFNKMMIDFKDIKNISLDHIMNNFKSFN
SESELDRDHFGFKTIDSKTYYYNEVGKLVKGSININDSLFYFDTIESNLV
TGWKTINGKTYYFDINNGVAYIGYKTIDGKNFYFDGNGIMQIGVFKVPDG
FKYFAPANTYNNNEEGQTIVYQNKFLTINGKKYYFDNNSKAVTGWQIING
NKYYFDTNTGIAAVGLQIINNNKYYFNPHTAIAATGWQSINNAKYYFDIN
TYIGTTGYKTIDSKNFYFDSNCIMQIGVFKVSDGFKYFAPANTYNNNEEG
QAIVYQNKFLTINGKRYYFDNNSKAVTGWHTIDGKKYYFNPNTAIAATGW
HTIDDKKYYFNPDTAIAATGWHTIDDKKYYFNPNTGITSTGETTINNKSF
YFNDKGIMQIGVFKVPDGFKYFAPANTHNNNLEGQAIVYQNKFLTINGKK
YYFDNNSKAITGWQVIDDKKYYFNSNTAVADTNLCTINNEKYYFSYDGIL
QNGYITIGRLNFYFDSNNDSKMTTGVFKGPNGFEYFAPANTYNNNLEGQA
IVYQNKFLTINGKKYYFDNKSKAVTGWQTIDGKKYYFNPNTAIAAMGWQA
IDGKKYYFNPNTAIATTGWQTIDGKKYYFNPNTAIAATGWQAIDGKKYYF
NPNTATTSIGYTTINSKNFYFNNDGIMQLGVFKGPDGFEYFAPANTHNNN
EEGQSITYQNKFLIFNEDVYYFDSSSKAVTGWRTIDDHRFYFEPNTGIGA
NGYKTLDGKNFYFRNGLPQFGVFKGPDGFEYFAPANTHNNNEEGQSITYQ
NKFLVFLGNRYYFDSSSKAVTGWQTINGNTYYFMPDTAIAAAGGFFTIDG
AIYFFGIDGVKQPGI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8jhz Chain A Residue 3000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jhz Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D545 H655 C700 H759
Binding residue
(residue number reindexed from 1)		D544 H654 C699 H758
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
GO:0008289 lipid binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0030430 host cell cytoplasm
GO:0044164 host cell cytosol
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jhz, PDBe:8jhz, PDBj:8jhz
PDBsum8jhz
PubMed38438396
UniProtM9ZTT7

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