Structure of PDB 8jew Chain A Binding Site BS01

Receptor Information
>8jew Chain A (length=512) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVS
QLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCP
PEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALL
NYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRN
LTFLIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARG
DIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACAR
LAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKV
GSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGL
SNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILI
VLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWLKSYDFPIGMGIVKRIT
FLKYIPICPVFK
Ligand information
Ligand IDASC
InChIInChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[CH](O)[CH]1OC(=O)C(=C1O)O
OpenEye OEToolkits 1.5.0C(C(C1C(=C(C(=O)O1)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
CACTVS 3.341OC[C@H](O)[C@H]1OC(=O)C(=C1O)O
ACDLabs 10.04O=C1OC(C(O)=C1O)C(O)CO
FormulaC6 H8 O6
NameASCORBIC ACID;
Vitamin C
ChEMBLCHEMBL196
DrugBankDB00126
ZINCZINC000100006770
PDB chain8jew Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8jew Cryo-EM structures of human vitamin C transporter SVCT1
Resolution2.49 Å
Binding residue
(original residue number in PDB)		C55 A109 S110 A111 F112 E334 T380 S381 S383
Binding residue
(residue number reindexed from 1)		C25 A79 S80 A81 F82 E290 T336 S337 S339
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008520 L-ascorbate:sodium symporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015205 nucleobase transmembrane transporter activity
GO:0015229 L-ascorbic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0007420 brain development
GO:0009636 response to toxic substance
GO:0015747 urate transport
GO:0015851 nucleobase transport
GO:0015882 L-ascorbic acid transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0030324 lung development
GO:0035725 sodium ion transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016324 apical plasma membrane
GO:0043229 intracellular organelle
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jew, PDBe:8jew, PDBj:8jew
PDBsum8jew
PubMed
UniProtQ9UHI7|S23A1_HUMAN Solute carrier family 23 member 1 (Gene Name=SLC23A1)

[Back to BioLiP]