Structure of PDB 8je1 Chain A Binding Site BS01

Receptor Information
>8je1 Chain A (length=675) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYP
EPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADY
MDCLYRYLNTQFIKKNKLTEADLQYGYGPLMEIGELALDMWRKLMVEPLQ
AILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEI
FESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHP
SSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVST
GLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINT
VLNGDQHFMSALDKALTSVVNYRKAPELLAKYCDNLLKKTENEVEDRLTS
FITVFKYIDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYE
FTSKLHRMYTDMSVSADLNNKFNNFISFQIYVLQAGAWPLTAIPQELEKS
VQMFELFYSQHFSGRKLTWLHYLCTGEVKMNMVTTYQMAVLLAFNNKELQ
DSTQMNEKELTKTIKSLLDVKMNHDSESSFSLNMNFRTKFTPQEMEQTRS
AVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
CIEVLIDKQYIERSQASADEYSYVA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8je1 Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Resolution3.95 Å
Binding residue
(original residue number in PDB)		S506 F507 Q508 I509 Y510 V511 L512 Q513 A514 L533 G550 R551 K552 T554 C560 T561 G562 E563 V564 K565
Binding residue
(residue number reindexed from 1)		S477 F478 Q479 I480 Y481 V482 L483 Q484 A485 L497 G514 R515 K516 T518 C524 T525 G526 E527 V528 K529
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031625 ubiquitin protein ligase binding
GO:0044877 protein-containing complex binding
GO:0160072 ubiquitin ligase complex scaffold activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0030891 VCB complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8je1, PDBe:8je1, PDBj:8je1
PDBsum8je1
PubMed38360992
UniProtQ13617|CUL2_HUMAN Cullin-2 (Gene Name=CUL2)

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