Structure of PDB 8jas Chain A Binding Site BS01

Receptor Information
>8jas Chain A (length=572) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQL
GSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCS
YIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEM
LHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKA
ALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKAC
VVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQ
SVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFH
AERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEA
HDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAI
QIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLF
GEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDA
LEDVSTSPQSTEEVVQSFLISQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jas Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Resolution3.54 Å
Binding residue
(original residue number in PDB)		Y338 Y341 Y345 R380 E387 Q427 K430 R437 Q440 S441 L472 H476 Y483 Y515 R518
Binding residue
(residue number reindexed from 1)		Y332 Y335 Y339 R374 E381 Q421 K424 R431 Q434 S435 L466 H470 Y477 Y509 R512
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jas, PDBe:8jas, PDBj:8jas
PDBsum8jas
PubMed37844242
UniProtQ92624|APBP2_HUMAN Amyloid protein-binding protein 2 (Gene Name=APPBP2)

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