Structure of PDB 8j86 Chain A Binding Site BS01

Receptor Information
>8j86 Chain A (length=993) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQS
LSPPPFNARPMGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSI
QNATMDEFFNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCF
AKEIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLL
FTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAK
QLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCI
YERNQSSHKNTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFS
CMGKVLNRGVREMTFIGDDTTDAKGKADTFAKVLTTGNYVTVDEDIICKV
IRKDILENGFKVVLSCPTLPNDIYKLSFGKDDIDLAQMYKDYNLNIALDM
ARYCIHDACLCQYLWEYYGVETKTDAGAATYVLPQSMVFEYRASTIIKGP
LLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYP
NVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRL
PNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDS
MQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGA
ELSNGMLRFANTLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSV
FTEIDSQDVDKSIEIAKELERLINSRVLFNNFKIEFEAVYKNLIMQSKKK
YTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLS
EGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADN
PNMYLVTEKNNPETIELGERYYFAYNVPWTKKLVNIKTYETIIDRSFKLG
SNQRIFYEVYFKRLTSEIVNLLDNKVLCISFFQRMFGSRPTFY
Ligand information
Receptor-Ligand Complex Structure
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PDB8j86 Structure of DNA replication machinery from human monkeypox virus in complex with a DNA duplex
Resolution3.22 Å
Binding residue
(original residue number in PDB)		K340 S893 K901 R1000
Binding residue
(residue number reindexed from 1)		K335 S888 K896 R989
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006310 DNA recombination
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8j86, PDBe:8j86, PDBj:8j86
PDBsum8j86
PubMed38735603
UniProtA0A7H0DN44|DPOL_MONPV DNA polymerase (Gene Name=OPG071)

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