Structure of PDB 8izm Chain A Binding Site BS01

Receptor Information
>8izm Chain A (length=1350) Species: 11168 (Mumps virus strain Jeryl Lynn) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIR
AEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDL
RQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAYS
IPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVD
TRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTA
SHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPV
IDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTA
ELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILI
NGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLR
IHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLP
QPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKA
TGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTM
NQIGIISEHGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHL
FEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGL
CQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEK
KEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRI
LTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLN
AFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNF
LSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWS
TLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEE
EELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEV
RPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIAR
SLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFT
WFFLPKGIRLDDDPASNPPIRVPYIGSKTDVASMAYIKGASVSLKSALRL
AGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRKF
TPASSYAFSSFVHISNDCQILTDSNLIYQQVMITGLALIETWNNPPINFS
VYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8izm Chain A Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8izm Structural insights into mumps virus polymerase complex for coordinating replication and transcription
Resolution3.01 Å
Binding residue
(original residue number in PDB)		C1187 C1190 H1372 H1374
Binding residue
(residue number reindexed from 1)		C1139 C1142 H1307 H1309
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8izm, PDBe:8izm, PDBj:8izm
PDBsum8izm
PubMed
UniProtQ9J4L0

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