Structure of PDB 8izl Chain A Binding Site BS01

Receptor Information

>8izl Chain A (length=2067) Species: 2560602 (Mumps orthorubulavirus)

LNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIR
AEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDL
RQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAYS
IPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVD
TRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTA
SHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPV
IDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTA
ELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILI
NGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLR
IHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLP
QPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKA
TGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTM
NQIGIISEHGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHL
FEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGL
CQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEK
KEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRI
LTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLN
AFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNF
LSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWS
TLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEE
EELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEV
RPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIAR
SLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFT
WFFLPKGIRLDDDPASNPPIRVPYIGSKTDVASMAYIKGASVSLKSALRL
AGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRKF
TPASSYAFSSFVHISNDCQILTDSNLIYQQVMITGLALIETWNNPPINFS
VYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLS
LLEMEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITTSNWIS
ECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPG
MAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGT
KQVLTNISQGIDYEIVVPSESSDRVLNLVARKLSLLAIIWANYNYPPKVK
GMSPEDKCQALTTHLLQTVEQIEKTNIRRMIIEPKLTAYPSNLLSRKLLN
AIRDSEEGQFLIASYYNLTEFDFILNLPQPPLHHVLRPLGLSSTSWYKTI
SVLNYISHMKISDGAHLYLAEGSGASMSLIETFLPGETIWYNSLFNSGEN
PPQRNFAPLPTQFIESVPYRLIQAGIAAGNGIVQSFYPLWNGNSDITDLS
TKTSVEYIIHKVGADTCALVHVDLEGLERAQVHALLITVTVLKPGGLLIL
KASWEPFNRFSFLLTVLWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPT
TSSFTTALNRARTLNEQGFSLIPPELVSEYWRKRVEQGQIIQDCIDKVIS
ECVRDQYLADNNIILQAGGTPSTRKWLDLPDYSSFNELQSEMARLITIHL
KEVIEILKGQAGPLGKINTILRLIVERILMYTVRNWCILPTQTRLTLRQS
IELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNR
AYQKRIWKAIGCVIYCF

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8izl Chain A Residue 3001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8izl Structural insights into mumps virus polymerase complex for coordinating replication and transcription
• Resolution: 2.93 Å
• Binding residue (original residue number in PDB): C1187 C1190 H1372 H1374
• Binding residue (residue number reindexed from 1): C1139 C1142 H1307 H1309
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.375: NNS virus cap methyltransferase.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.88: GDP polyribonucleotidyltransferase.
  3.6.1.-

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
• GO:0005524 ATP binding
• GO:0008168 methyltransferase activity
• GO:0016740 transferase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006370 7-methylguanosine mRNA capping
• GO:0032259 methylation
• GO:0106005 RNA 5'-cap (guanine-N7)-methylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0030430 host cell cytoplasm
• GO:0044423 virion component

External links

• PDB: RCSB:8izl, PDBe:8izl, PDBj:8izl
• PDBsum: 8izl
• PubMed: 38760379
• UniProt: Q9J4L0