Structure of PDB 8ity Chain A Binding Site BS01

Receptor Information
>8ity Chain A (length=1378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLL
YGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVI
GILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRK
KNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIE
HNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLIL
TRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAK
TQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRF
RGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANIN
FLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVER
HLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDG
DEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLL
TLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFS
VILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDK
GTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGD
VTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALI
LKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQ
AISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTM
AGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIY
GGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESI
MKKSEFLCCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQ
LDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKT
FHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVK
GRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYS
ICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQ
GIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTY
EVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLG
ITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIP
MNIGTGLFKLLHKADRDPNPPKRPLIFD
Ligand information
>8ity Chain Y (length=82) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaagcgagcacggtgtttcgtcctttccacaagatatataaagccaagaa
atcgaaatactttcaagttacggtaagcatat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ity Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K183 N331
Binding residue
(residue number reindexed from 1)		K181 N329
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042797 tRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ity, PDBe:8ity, PDBj:8ity
PDBsum8ity
PubMed37165065
UniProtO14802|RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (Gene Name=POLR3A)

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