Structure of PDB 8itn Chain A Binding Site BS01

Receptor Information
>8itn Chain A (length=350) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YAIPVDENGHRYVGLVNQAMTCYLNSLVQSLYMTPEFRNAMYDKKAEQSI
PCQLQKLFLLLQTSENDSLETKDLTQSFGWTSNEAYDQHDVQELCRLMFD
ALEHKWKGTEHEKLIQDLYRGTMEDFVACLKCGRESVKTDYFLDLPLAVK
PFGAIHAYKSVEEALTAFVQPELLDGSNQYMCENCKSKQDAHKGLRITQF
PYLLTIQLKRFDFDYNTMHRIKLNDKMTFPDVLDLNDYVCVGQPIDHAAV
DDIVKTSGDNVYELFSVMVHSGNAAGGHYFAYIKNLDQDRWYVFNDTRVD
FATPLEIEKSFGGHPSGWNQSNTNAYMLMYRRIDPKRNARFILSNQLPQH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8itn Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8itn Structural and functional characterization of USP47 reveals a hot spot for inhibitor design
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C218 C221 C271 C274
Binding residue
(residue number reindexed from 1)		C129 C132 C182 C185
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:8itn, PDBe:8itn, PDBj:8itn
PDBsum8itn
PubMed37740002
UniProtQ22240

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