Structure of PDB 8irm Chain A Binding Site BS01

Receptor Information
>8irm Chain A (length=540) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKLLNRLNTYVGSSRVGKRFKLAERNSTFTTELRAGTATFLTMAYILAVN
ASILSDSGGTCSVSDCIPLCSNPAIEPSQCTGPGLRLIQPDVSCKFNPVN
PGYAACVEEIRKDLIVATVAASLIGCVIMGLMANLPLALAPGMGTNAYFA
YTVVGFHGSGSISYRTALAAVFIEGLIFLFISAIGFRAKLAKLVPKPVRI
SSSAGIGLFLAFIGLQNNQGIGLVGYSPSTLVTLAACPASSRISLAPVIT
SANGTVSLLAGGSVSGDIMCIHGRMESPTFWLGIVGFVIIAYCLVKNVKG
AMIYGIVFVTAVSWFRNTEVTAFPNTSAGDAAHDYFKKIVDVHVIKHTAG
ALSFSGINKGHFWEALVTFLYVDILDTTGTLYSMARFAGFVDEKGDFAGQ
YFAFMSDASAIVIGSLLGTSPVTVFIESSTGIREGGRTGLTAITVAVYFL
LAMFFTPLLASIPAWAVGPPLILVGVMMMKSVTEIDWEDMREAIPAFVTM
ILMPLTYSVAYGLIGGIGSYVVLHLWDWGEEGLVKLGFLK
Ligand information
Ligand IDADE
InChIInChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
InChIKeyGFFGJBXGBJISGV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ncnc2[nH]cnc12
OpenEye OEToolkits 1.5.0c1[nH]c2c(n1)c(ncn2)N
ACDLabs 10.04n1c(c2ncnc2nc1)N
FormulaC5 H5 N5
NameADENINE
ChEMBLCHEMBL226345
DrugBankDB00173
ZINCZINC000000000882
PDB chain8irm Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8irm Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Y62 G159 M160 D393 T440 V441 F442 I443 E444
Binding residue
(residue number reindexed from 1)		Y45 G142 M143 D376 T423 V424 F425 I426 E427
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005345 purine nucleobase transmembrane transporter activity
GO:0015205 nucleobase transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006863 purine nucleobase transport
GO:0015853 adenine transport
GO:0015854 guanine transport
GO:0055085 transmembrane transport
GO:1904823 purine nucleobase transmembrane transport
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8irm, PDBe:8irm, PDBj:8irm
PDBsum8irm
PubMed38172575
UniProtQ9SRK7|AZG1_ARATH Adenine/guanine permease AZG1 (Gene Name=AZG1)

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