Structure of PDB 8iey Chain A Binding Site BS01

Receptor Information
>8iey Chain A (length=329) Species: 63363 (Aquifex aeolicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSARE
HTRNILPIFDRLLKESRINLEEIDFISFTLTPGLILSLVVGVAFAKALAY
EYRKPLVPVHHLEGHIYSVFLEKKVEYPFLALIISGGHTDLYLVRDFGRY
DFLGGTLDDAVGEAYDKVAKMLGLGYPGGPIIDRLAKEGKKLYPLPKPLM
EEGNLNFSFSGLKTAILNLVRKEDIAYSFQETVVEILLEKSLWAMKKTGI
KRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALMIAYAGM
ERFKRGVVAPLDVNPQPNIPLEEFGRIWT
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain8iey Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8iey Crystal structure of Aquifex aeolicus TsaD-TsaB complex
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H111 H115 D296
Binding residue
(residue number reindexed from 1)		H111 H115 D290
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8iey, PDBe:8iey, PDBj:8iey
PDBsum8iey
PubMed
UniProtO66986|TSAD_AQUAE tRNA N6-adenosine threonylcarbamoyltransferase (Gene Name=tsaD)

[Back to BioLiP]