Structure of PDB 8idf Chain A Binding Site BS01

Receptor Information
>8idf Chain A (length=459) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVESLPRGGFRCSLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLR
SVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGARE
AVLSQSQHSLGGHRLRVRPREQKEFQSPDSHQLAKALAEAADVGAQMIKL
VGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCD
LALFLDLGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFAHRPSGLH
GDVSLSNRLALHNSRFLSLASELDGRVRPLVYTLRAWAQGRGLSGSGPLL
SNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDA
SRLEPSINVEPLSSLLAQFFSAVSSWDLRGSLLSLREGQALEGLRLGPLN
LQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYARSLQYQRRSSRGRDWG
LLPLLQPSS
Ligand information
>8idf Chain B (length=53) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggauacuaaaauuggaacgauacagaguucgcucgugaagcguuccauau
uuu
.........<<<<<<<<<<.<<<.<<<....>>>>>>...>>>>>>>.>>
>..
Receptor-Ligand Complex Structure
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PDB8idf Mechanism of U6 snRNA oligouridylation by human TUT1.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		V23 N27 S30 A33 H34 G37 R38 H42 R50 Q53 F59 G62 K89 K91 V93 R124 P125 R126 E127 G204 D216 R349 Y356 Q359 V361 K370 R374 D381 N386 A389 N392 P427 Y432 R535 H549 R558
Binding residue
(residue number reindexed from 1)		V17 N21 S24 A27 H28 G31 R32 H36 R44 Q47 F53 G56 K83 K85 V87 R118 P119 R120 E121 G188 D200 R220 Y227 Q230 V232 K241 R245 D252 N257 A260 N263 P298 Y303 R395 H409 R418
Enzymatic activity
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.52: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8idf, PDBe:8idf, PDBj:8idf
PDBsum8idf
PubMed37563152
UniProtQ9H6E5|STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Gene Name=TUT1)

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