Structure of PDB 8iak Chain A Binding Site BS01

Receptor Information
>8iak Chain A (length=495) Species: 3702,559292 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHFFVEGLLGVVIIILLTRKSYKPPKRPLTEQEIDELCDEWVPEPLVDPS
ATDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLS
ATEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSV
LYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHN
DMNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKL
KNKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALG
STGGFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDA
VQTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFG
YTCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLITR
NTIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACCQ
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8iak Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8iak Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S385 A386
Binding residue
(residue number reindexed from 1)		S326 A327
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Gene Ontology
Molecular Function
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8iak, PDBe:8iak, PDBj:8iak
PDBsum8iak
PubMed38285738
UniProtP25045|SPTC1_YEAST Serine palmitoyltransferase 1 (Gene Name=LCB1);
Q94IB8|SPTC1_ARATH Long chain base biosynthesis protein 1 (Gene Name=LCB1)

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