Structure of PDB 8hz5 Chain A Binding Site BS01

Receptor Information

>8hz5 Chain A (length=350) Species: 324602 (Chloroflexus aurantiacus J-10-fl)

IRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCI
GPPPAAKSYLNAPALISAALVSGCDAIHPGYGFLSENPYFAEMCADCKLT
FIGPPPEPIRLMGDKAIGRETMRKAGVPTVPSLEEAIDVARQIVRHVEIQ
VLADQYGHAIHLGERDCKIVEEAPSPAVTPELRERMGADAVRGIKSIGYV
NAGTLEFLLDQDGNYYFIEMNTRIQVEHPVTEQVTGIDLVRWQLLIASGE
RLTLRQEDIKITRHAIECRINAEVEFYLPPGGPGVRVDSHLYSGYTPPGT
YDSLLAKIITFGDTRDEALNRMRRALNECVITGIKTTIPFQLALIDDPEF

Ligand information

• Ligand ID: BCT
• InChI: InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
• InChIKey: BVKZGUZCCUSVTD-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.5.0: C(=O)(O)[O-]
  CACTVS 3.341: OC([O-])=O
  ACDLabs 10.04: [O-]C(=O)O
• Formula: C H O3
• Name: BICARBONATE ION
• PDB chain: 8hz5 Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hz5 The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R292 Q294 V295 E296
• Binding residue (residue number reindexed from 1): R223 Q225 V226 E227
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 6.3.4.14: biotin carboxylase.

Gene Ontology

Molecular Function

• GO:0003989 acetyl-CoA carboxylase activity
• GO:0004075 biotin carboxylase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0006633 fatty acid biosynthetic process
• GO:2001295 malonyl-CoA biosynthetic process

External links

• PDB: RCSB:8hz5, PDBe:8hz5, PDBj:8hz5
• PDBsum: 8hz5
• PubMed: 38572988
• UniProt: A9WKH8