Structure of PDB 8hwh Chain A Binding Site BS01

Receptor Information

>8hwh Chain A (length=353) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIR
HQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDL
VDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLT
DENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGD
LFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSD
NIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIA
VVRFRTHLDGKIQNNRYRFAFLYLLVKWYKKYHIPIMKLYPTPEEIPDFA
FYL

Ligand information

>8hwh Chain S (length=6) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hwh Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	R585 F588
Binding residue (residue number reindexed from 1)	R263 F266

Enzymatic activity

Enzyme Commision number

3.6.4.-

Gene Ontology

	Molecular Function
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

	Cellular Component
GO:0030430	host cell cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8hwh, PDBe:8hwh, PDBj:8hwh
PDBsum	8hwh
PubMed	38177671
UniProt	A0A7H0DN89\|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

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