Structure of PDB 8htg Chain A Binding Site BS01

Receptor Information
>8htg Chain A (length=332) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEKKQKILDIRKNVKDAIV
TIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLW
DDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLT
SGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYN
MVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAG
KSKIEDYFPEYANYTVPEDTPDAGEDPKVTRAKFFIRDLFLRISTATGDG
KHYCYPHFTCAVDTENIRRVFNDCRDIIQRMH
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8htg Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8htg Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Resolution2.91 Å
Binding residue
(original residue number in PDB)		S56 T191
Binding residue
(residue number reindexed from 1)		S16 T150
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001975 response to amphetamine
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0031000 response to caffeine
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8htg, PDBe:8htg, PDBj:8htg
PDBsum8htg
PubMed38062020
UniProtQ8CGK7|GNAL_MOUSE Guanine nucleotide-binding protein G(olf) subunit alpha (Gene Name=Gnal)

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