Structure of PDB 8hr0 Chain A Binding Site BS01

Receptor Information
>8hr0 Chain A (length=708) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLP
PIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGIS
ELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQ
MSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQE
MLGPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIA
VGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNA
KYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYM
VMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIG
PCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVGRGAIQF
VTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAI
YRAETEDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHL
RRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEP
VLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHL
LQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNDVSLQVFMDHL
KKLAVSSA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hr0 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hr0 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations
Resolution3.34 Å
Binding residue
(original residue number in PDB)		C61 C66 C85
Binding residue
(residue number reindexed from 1)		C59 C64 C83
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0072659 protein localization to plasma membrane
GO:0090110 COPII-coated vesicle cargo loading
GO:0090114 COPII-coated vesicle budding
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hr0, PDBe:8hr0, PDBj:8hr0
PDBsum8hr0
PubMed
UniProtQ15436|SC23A_HUMAN Protein transport protein Sec23A (Gene Name=SEC23A)

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