Structure of PDB 8hpk Chain A Binding Site BS01

Receptor Information
>8hpk Chain A (length=390) Species: 847 (Oxalobacter formigenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLLGNRWFYLVLAVLLMCMISGVQYSWTLYANPVKDNLGVSLAAVQTAFT
LSQVIQAGSQPGGGYFVDKFGPRIPLMFGGAMVLAGWTFMGMVDSVPALY
ALYTLAGAGVGIVYGIAMNTANRWFPDKRGLASGFTAAGYGLGVLPFLPL
ISSVLKVEGVGAAFMYTGLIMGILIILIAFVIRFPGQQIVVTDKDFNSGE
MLRTPQFWVLWTAFFSVNFGGLLLVANSVPYGRSLGLAAGVLTIGVSIQN
LFNGGCRPFWGFVSDKIGRYKTMSVVFGINAVVLALFPTIAALGDVAFIA
MLAIAFFTWGGSYALFPSTNSDIFGTAYSARNYGFFWAAKATASIFGGGL
GAAIATNFGWNTAFLITAITSFIAFALATFVIPRMGRPVK
Ligand information
Ligand IDOXL
InChIInChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKeyMUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0C(=O)(C(=O)[O-])[O-]
FormulaC2 O4
NameOXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain8hpk Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hpk Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q34 Y35 Y124 Y150 R272 Y328 K355
Binding residue
(residue number reindexed from 1)		Q24 Y25 Y114 Y140 R257 Y313 K340
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015297 antiporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019532 oxalate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hpk, PDBe:8hpk, PDBj:8hpk
PDBsum8hpk
PubMed37012268
UniProtQ51330|OXLT_OXAFO Oxalate:formate antiporter (Gene Name=oxlT)

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