Structure of PDB 8ho8 Chain A Binding Site BS01

Receptor Information
>8ho8 Chain A (length=809) Species: 1515 (Acetivibrio thermocellus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFGFFDDANKEYVITVPRTPYPWINYLGTENFFSLISNTAGGYCFYRDAR
LRRITRYRYNNVPIDMGGRYFYIYDNGDFWSPGWSPVKRELESYECRHGL
GYTKIAGKRNGIKAEVTFFVPLNYNGEVQKLILKNEGQDKKKITLFSFIE
FCLWNAYDDMTNFQRNFSTGEVEIEGSVIYHKTEYRERRNHYAFYSVNAK
ISGFDSDRDSFIGLYNGFDAPQAVVNGKSNNSVADGWAPIASHSIEIELN
PGEQKEYVFIIGYVENKDEEKWESKGVINKKKAYEMIEQFNTVEKVDKAF
EELKSYWNALLSKYFLESHDEKLNRMVNIWNQYQCMVTFNMSRSASYFES
GIGRGMGFRDSNQDLLGFVHQIPERARERLLDLAATQLEDGSAYHQYQPL
TKKGNNEIGSNFNDDPLWLILATAAYIKETGDYSILKEQVPFNNDPSKAD
TMFEHLTRSFYHVVNNLGPHGLPLIGRADWNDCLNLNCFSTVPDESFQTT
TSKDGKVAESVMIAGMFVFIGKDYVKLCEYMGLEEEARKAQQHIDAMKEA
ILKYGYDGEWFLRAYDDFGRKVGSKENEEGKIFIESQGFCVMAEIGLEDG
KALKALDSVKKYLDTPYGLVLQNPAFTRYYIEYGEISTYPPGYKENAGIF
CHNNAWIICAETVVGRGDMAFDYYRKIAPAYIEDVSDIHKLEPYVYAQMV
AGKDAKRHGEAKNSWLTGTAAWNFVAISQWILGVKPDYDGLKIDPCIPKA
WDGYKVTRYFRGSTYEITVKNPNHVSKGVAKITVDGNEISGNILPVFNDG
KTHKVEVIL
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain8ho8 Chain C Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ho8 The cryo-EM structure of cellobiose phosphorylase from Clostridium thermocellum in complex with cellobiose
Resolution2.24 Å
Binding residue
(original residue number in PDB)		C484 E636 Y640 K645 E646
Binding residue
(residue number reindexed from 1)		C483 E635 Y639 K644 E645
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.1.20: cellobiose phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0047738 cellobiose phosphorylase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0030245 cellulose catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ho8, PDBe:8ho8, PDBj:8ho8
PDBsum8ho8
PubMed
UniProtQ8VP44

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