Structure of PDB 8hn9 Chain A Binding Site BS01

Receptor Information
>8hn9 Chain A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYD
LPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLL
LRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADV
MADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL
EVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVES
LVELLGWTEEMRDLVQRETGKLD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hn9 SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		H248 E296 V324
Binding residue
(residue number reindexed from 1)		H126 E174 V202
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:8hn9, PDBe:8hn9, PDBj:8hn9
PDBsum8hn9
PubMed36896611
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

[Back to BioLiP]