Structure of PDB 8hly Chain A Binding Site BS01

Receptor Information
>8hly Chain A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQY
DLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGL
LLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRAD
VMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTS
LEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVE
SLVELLGWTEEMRDLVQRET
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hly Identification of SIRT3 as an eraser of H4K16la.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H248 V292 F293 F294 G295 E296 L322 E323 V324 E325 W353
Binding residue
(residue number reindexed from 1)		H127 V171 F172 F173 G174 E175 L201 E202 V203 E204 W232
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:8hly, PDBe:8hly, PDBj:8hly
PDBsum8hly
PubMed37720100
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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