Structure of PDB 8hlw Chain A Binding Site BS01

Receptor Information
>8hlw Chain A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSDLPYPEAI
FELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQN
IDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPR
CPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFAS
LTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGW
TEEMRDLVQRETGKLD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hlw Identification of SIRT3 as an eraser of H4K16la.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H248 V292 F293 F294 G295 E296 L298 L322 E323 E325
Binding residue
(residue number reindexed from 1)		H119 V163 F164 F165 G166 E167 L169 L193 E194 E196
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:8hlw, PDBe:8hlw, PDBj:8hlw
PDBsum8hlw
PubMed37720100
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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