Structure of PDB 8hl8 Chain A Binding Site BS01

Receptor Information
>8hl8 Chain A (length=371) Species: 531310 (Marinactinospora thermotolerans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDISTAVVVTTISDGGFLDRLAPALRDAGARLIVIPDRNTGPALFAACER
HRRLGLDVVCPSVAEQQDLLERLAVPDLIPYHSDNRRNVGYLMAWMEGFD
VIVSMDDDNLPTTDDFVERHQVVCQGPRTQPVTASSDGWFNNCALLEVEP
TEVFPRGFPFHARPAHAQARTSVCERPADVRINAGLWLGDPDVDAITRLA
VRPNALAHSGGSVVLAEGTWCPVNSQNTAVHRDALPAYYFLRMGQPVDGV
PMEKFGDIFSGYFVQVCAQHLGHAVRFGDPVVEHPRNEHDLLDDLHKEVP
AVRLLDDILDHLRDHPLEGGDYLETYESLSYALQEIAERVNGRAWSPDAR
AFLHRSAHLMRSWTGALRTVA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8hl8 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hl8 Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D111 H287
Binding residue
(residue number reindexed from 1)		D108 H284
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8hl8, PDBe:8hl8, PDBj:8hl8
PDBsum8hl8
PubMed36642179
UniProtG8HX37

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