Structure of PDB 8hkw Chain A Binding Site BS01

Receptor Information
>8hkw Chain A (length=415) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPH
QNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNV
TWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT
DAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQ
VVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLV
PMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL
TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHEN
EDIYKLAYEIIDQFF
Ligand information
>8hkw Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GKRKLITSEEERSPAKRGRKS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hkw Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D271 R306 V312 T313 W348 N352 E387 W390
Binding residue
(residue number reindexed from 1)		D201 R236 V242 T243 W278 N282 E317 W320
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8hkw, PDBe:8hkw, PDBj:8hkw
PDBsum8hkw
PubMed36875212
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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