Structure of PDB 8hir Chain A Binding Site BS01

Receptor Information
>8hir Chain A (length=918) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRV
LLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVA
IISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNL
FIPVFLNCWLAKHALENMINDFHRSAMFNQVLILFCTLLCLVFTGTCGIQ
HLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALV
VLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFL
NEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQ
DLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQ
ILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ
EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKK
YGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFVEYVK
GYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNK
LIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAIC
CFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKT
IVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERE
NGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTT
PGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHAAEWI
SQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDHQNTLSYVLINPPPD
TRLEPSDIVYLIRSDPLA
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain8hir Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hir Structural basis of human Slo2.2 channel gating and modulation.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		L532 H535 S537 S557 G558 N559 E560
Binding residue
(residue number reindexed from 1)		L442 H445 S447 S467 G468 N469 E470
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hir, PDBe:8hir, PDBj:8hir
PDBsum8hir
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

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