Structure of PDB 8hhl Chain A Binding Site BS01

Receptor Information
>8hhl Chain A (length=592) Species: 56689 (Mycolicibacterium mucogenicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTMTVHTMGVHYKWQIPEVLRQQLWLAHNLREDLVSLQLAYDDDLKAIW
SSYPDVAQAEDTMAAAEADAVALSERVKQARIEARSKKISTELTQQLRDA
KKRLKDARQARRDAIAVVKDDAAERRKARSDQLAADQKALYGQYCRDGDL
YWASFNTVLDHHKTAVKRIAAQRASGKPATLRHHRFDGSGTIAVQLQRQA
GAPPRTPMVLADEAGKYRNVLHIPGWTDPDVWEQMTRSQCRQSGRVTVRM
RCGSTDGQPQWIDLPVQVHRWLPADADITGAELVVTRVAGIYRAKLCVTA
RIGDTEPVTSGPTVALHLGWRSTEEGTAVATWRSDAPLDIPFGLRTVMRV
DAAGTSGIIVVPATIERRLTRTENIASSRSLALDALRDKVVGWLSDNDAP
TYRDAPLEAATVKQWKSPQRFASLAHAWKDNGTEISDILWAWFSLDRKQW
AQQENGRRKALGHRDDLYRQIAAVISDQAGHVLVDDTSVAELSARAMERT
ELPTEVQQKIDRRRDHAAPGGLRASVVAAMTRDGVPVTIVAAADFTRTHS
RCGHVNPADDRYLSNPVRCDGCGAMYDQDRSFVTLMLRAATA
Ligand information
>8hhl Chain B (length=49) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcccagcuuggcgggcgaaggccaagacggagaugaggugcgcguggc
.((((.<<<<<<<))))....>>>>>>.>....................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hhl Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		V6 Y13 K14 R85 H161 T180 L181 R182 H184 R237 S238 R241 R245 Q267 H269 R270 E282 R293 K295 R368 E373 S377 S380 L381 D384 R447 K448 Q452 N455 G456 K459 H463 D466 R469 A494 D511 R512 D515 R532
Binding residue
(residue number reindexed from 1)		V6 Y13 K14 R85 H161 T180 L181 R182 H184 R237 S238 R241 R245 Q267 H269 R270 E282 R293 K295 R368 E373 S377 S380 L381 D384 R447 K448 Q452 N455 G456 K459 H463 D466 R469 A494 D511 R512 D515 R532
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8hhl, PDBe:8hhl, PDBj:8hhl
PDBsum8hhl
PubMed37460897
UniProtP0DXB1|CS12M_MYCMU CRISPR-associated DNA-binding protein Cas12m (Gene Name=cas12m)

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