Structure of PDB 8hfc Chain A Binding Site BS01

Receptor Information
>8hfc Chain A (length=276) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASF
IRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKY
CPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLG
AILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYH
IFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLE
PRGPSFVSARKPHEAGDWRFMDLSPA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hfc Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hfc Cryo-EM structure of Yeast Erf2/Erf4 complex
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C189 H202
Binding residue
(residue number reindexed from 1)		C115 H128
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0016746 acyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
Biological Process
GO:0006612 protein targeting to membrane
GO:0018345 protein palmitoylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031211 endoplasmic reticulum palmitoyltransferase complex
GO:0032541 cortical endoplasmic reticulum
GO:0097038 perinuclear endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hfc, PDBe:8hfc, PDBj:8hfc
PDBsum8hfc
PubMed38182928
UniProtQ06551|ERFB_YEAST Palmitoyltransferase ERF2 (Gene Name=ERF2)

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