Structure of PDB 8hf3 Chain A Binding Site BS01

Receptor Information
>8hf3 Chain A (length=295) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECR
YLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEME
IEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSIC
DNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVAL
KSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNE
DIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hf3 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hf3 Cryo-EM structure of human ZDHHC9/GCP16 complex
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C141 C144 H154
Binding residue
(residue number reindexed from 1)		C133 C136 H146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016409 palmitoyltransferase activity
GO:0016746 acyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0043849 Ras palmitoyltransferase activity
Biological Process
GO:0000165 MAPK cascade
GO:0006612 protein targeting to membrane
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation
GO:0044794 positive regulation by host of viral process
GO:0140639 positive regulation of pyroptotic inflammatory response
GO:0141111 positive regulation of cGAS/STING signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0002178 palmitoyltransferase complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hf3, PDBe:8hf3, PDBj:8hf3
PDBsum8hf3
PubMed38182928
UniProtQ9Y397|ZDHC9_HUMAN Palmitoyltransferase ZDHHC9 (Gene Name=ZDHHC9)

[Back to BioLiP]