Structure of PDB 8he0 Chain A Binding Site BS01
Receptor Information
>8he0 Chain A (length=422) Species:
10090
(Mus musculus) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF
Ligand information
>8he0 Chain B (length=13) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
QRKRKMSWKRVKG
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
8he0
Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
W142 N146 A148 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 D270 G281 R315 V321 T322 W357 N361 A364 G365 E396 W399 N403 G407
Binding residue
(residue number reindexed from 1)
W68 N72 A74 S75 G76 T81 Q107 W110 N114 G117 D118 W157 R164 D196 G207 R241 V247 T248 W283 N287 A290 G291 E322 W325 N329 G333
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8he0
,
PDBe:8he0
,
PDBj:8he0
PDBsum
8he0
PubMed
36806083
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
[
Back to BioLiP
]
