Structure of PDB 8haw Chain A Binding Site BS01

Receptor Information
>8haw Chain A (length=479) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPIKTIVVLVQENRSFDHTLGWFKELNREIDGVTKSDPKSNTVSNSLRVV
FGDQSQYVNPDPGHSIQDIYEQVFGKPWDSGKPDPNPGHPNMSGFAQNAE
RNKKGMSSAVMNGFKPNALPVYKELVQNFAICDRWFASVPASTQPNRLYV
HSATSHGATSNDAALLLEGFPQKTIFESLDEAGFSFGIYYQFPPSTLFYR
NLRKLKYLTHFHQYGIQFKKDCKEGKLPNYVVVEQRWFDLLSTPANDDHP
SHDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPVDGV
PNPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVIHGPNGPYPRSQY
EHSSIPATVKTIFKLKDFLSKRDSWAGTFESVITRDSPRQDCPETLSTPI
KLRGTMAKENAQLSEFQEDLVIMAAGLKGDYKNEELIHKLCKETCVADAS
KYVTNAFEKFLEESRKARDRGCDENDIVY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8haw Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8haw Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E23x N24x T158x D299x E300x
Binding residue
(residue number reindexed from 1)		E12 N13 T143 D284 E285
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.3: phospholipase C.
Gene Ontology
Molecular Function
GO:0004629 phospholipase C activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0034480 phosphatidylcholine phospholipase C activity
Biological Process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8haw, PDBe:8haw, PDBj:8haw
PDBsum8haw
PubMed36635324
UniProtQ9SRQ7|NPC4_ARATH Non-specific phospholipase C4 (Gene Name=NPC4)

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