Structure of PDB 8hav Chain A Binding Site BS01

Receptor Information
>8hav Chain A (length=399) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPIKTIVVLVQENRSFDHTLGWFKELNREIDGVTKSDPKSNTVSSSDTNS
LRVVFGDQSQYVNPDPGHSIQDIYEQVFGKPWDSGKPDPNPGHPNMSGFA
QNAERNKKGMSSAVMNGFKPNALPVYKELVQNFAICDRWFASVPASTQPN
RLYVHSATSHGATSNDAALLLEGFPQKTIFESLDEAGFSFGIYYQFPPST
LFYRNLRKLKYLTHFHQYGIQFKKDCKEGKLPNYVVVEQRWFDLLSTHPS
HDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPVDGVP
NPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVIHGPNGPYPRSQYE
HSSIPATVKTIFKLKDFLSKRDSWAGTFESVITRDSPRQDCPETLSTPI
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain8hav Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hav Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		K91 K97
Binding residue
(residue number reindexed from 1)		K80 K86
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.3: phospholipase C.
Gene Ontology
Molecular Function
GO:0004629 phospholipase C activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0034480 phosphatidylcholine phospholipase C activity
Biological Process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hav, PDBe:8hav, PDBj:8hav
PDBsum8hav
PubMed36635324
UniProtQ9SRQ7|NPC4_ARATH Non-specific phospholipase C4 (Gene Name=NPC4)

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