Structure of PDB 8gzq Chain A Binding Site BS01

Receptor Information
>8gzq Chain A (length=852) Species: 12637 (Dengue virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLGEKWKKRLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTYRRPTIEKDVD
LGAGTRHVNAEPETPNMDVIGERIRRIKEEHSSTWHYDDENPYKTWAYHG
SYEVKASMINGVVKLLTKPWDVVPTVTQMAMTDTTPFGQQRVFKEKVDTR
TPKPMPGTRKVMEITAGWLWRTLGRNKRPRLCTREEFTKKVRTNQWDSAR
AAVEDEEFWKLVDRERELHKQGKCGSCVYNMMRAIWYMWLGARYLEFEAL
GFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWD
TRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPKGTV
MDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKTDLENPHL
LEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVR
KDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRA
RISQGAGWSLKETACLGKAYAQMWALMYFHRRDLRLASNAICSAVPVHWV
PTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEDNPWMEDKTPVTTWEDVPY
LGKREDQWCGSLIGLTSRATWAQNILTAIQQVRSLIGNEEFLDYMPSMKR
FR
Ligand information
>8gzq Chain S (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguuguuagucuguguggaccgacaaggacaguuccaaaucggaagcugc
uuaacacaguucuaac
....<<<<<.<<<<<<...<<<<...<<<....>>>...>>>><<<...>
>>.>>>>>>..>>>>>
Receptor-Ligand Complex Structure
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PDB8gzq Structures of dengue virus RNA replicase complexes.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		E43 S56 R57 R84 G148 E149 S150 E216 Y838 R842 R856 M886 K887 R888
Binding residue
(residue number reindexed from 1)		E37 S50 R51 R78 G142 E143 S144 E210 Y800 R804 R818 M848 K849 R850
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8gzq, PDBe:8gzq, PDBj:8gzq
PDBsum8gzq
PubMed37478848
UniProtQ5I3C1

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