Structure of PDB 8gzp Chain A Binding Site BS01

Receptor Information
>8gzp Chain A (length=854) Species: 12637 (Dengue virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLGEKWKKRLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTYRRPTIEKDVD
LGAGTRHVNAEPETPNMDVIGERIRRIKEEHSSTWHYDDENPYKTWAYHG
SYEVKATMINGVVKLLTKPWDVVPTVTQMAMTTPFGQQRVFKEKVDTRTP
KPMPGTRKVMEITAGWLWRTLGRNKRPRLCTREEFTKKVRTNAEENQWDS
ARAAVEDEEFWKLVDRERELHKQGKCGSCVYNMMRAIWYMWLGARYLEFE
ALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAG
WDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPKG
TVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKTDLENP
HLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGK
VRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIG
RARISQGAGWSLKETACLGKAYAQMWALMYFHRRDLRLASNAICSAVPVH
WVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEDNPWMEDKTPVTTWEDV
PYLGKREDQWCGSLIGLTSRATWAQNILTAIQQVRSLIGNEEFLDYMPSM
KRFR
Ligand information
>8gzp Chain S (length=67) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguuguuagucuguguggaccgacaaggacaguuccaaaucggaagcugc
uuaacacaguucuaaca
...<<<<<<.<<<<<<...<<<<...<<<....>>>...>>>><<<...>
>>.>>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8gzp Structures of dengue virus RNA replicase complexes.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K42 R57 E111 G148 S150 K180 K719 R770 Y838 K841 R856 M886 K887 R888
Binding residue
(residue number reindexed from 1)		K36 R51 E105 G142 S144 K174 K683 R734 Y802 K805 R820 M850 K851 R852
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8gzp, PDBe:8gzp, PDBj:8gzp
PDBsum8gzp
PubMed37478848
UniProtQ5I3C1

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