Structure of PDB 8gvd Chain A Binding Site BS01
Receptor Information
>8gvd Chain A (length=306) Species:
2697049
(Severe acute respiratory syndrome coronavirus 2) [
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SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ
Ligand information
>8gvd Chain B (length=3) Species:
32630
(synthetic construct) [
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AIF
Receptor-Ligand Complex Structure
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PDB
8gvd
SARS-CoV-2 Mpro in complex with D-4-38
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
T24 T25 T26 C44 S46 N142 G143 C145
Binding residue
(residue number reindexed from 1)
T24 T25 T26 C44 S46 N142 G143 C145
Enzymatic activity
Enzyme Commision number
2.1.1.56
: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57
: methyltransferase cap1.
2.7.7.48
: RNA-directed RNA polymerase.
2.7.7.50
: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12
: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69
: SARS coronavirus main proteinase.
3.6.4.12
: DNA helicase.
3.6.4.13
: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0008233
peptidase activity
Biological Process
GO:0019082
viral protein processing
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:8gvd
,
PDBe:8gvd
,
PDBj:8gvd
PDBsum
8gvd
PubMed
UniProt
P0DTD1
|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)
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