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Receptor Information

>8gcc Chain A (length=707) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LGIPKLDDANEAGGKYSHRCTLILTEGDSAKALCTAGLAVKDRDYFGVFP
LRGKPLNVRDATLKKVMACAEFQAVSKIMGLDIRQKYSGVERLRYGHLMI
MSDQDHDGSHIKGLIINMIHHYWPDLIKTPGFLQQFITPIVKARISFFSM
PDYFEWKNAIGDGIRNYEIRYYKGLGTSGAKEGREYFENIDRHRLDFVHE
DATDDARIVMAFAKDKVEERKHWITQFKANTNVNESMNYNVRTVRYSEFV
DKELILFSVADCERSIPSVIDGLKPGQRKIIFSSFKRRLTRSIKVVQLAG
YVSEHAAYHHGEQSLVQTIVGLAQNFVGSNNVPLLQQDGQFGTRLQGGKD
HAAGRYIFTRLTNIARYIYHPSDDFVVDYKDDDGLSVEPFYYVPVIPMVL
VNGTSGIGTGFATNIPNYSPLEVIDNLMRLLRGEEVQPMKPWYFGFAGTI
EEKEKGKFVSTGCANVRPDGVVQITELPIGTWTQGYKKFLEELREKEVVV
QYREHNTDVTVDFEVFLHPEVLHHWVAQGCVEERLQLREYIHATNIIAFD
REGQITKYRDAEAVLKEFYLVRLEYYAKRRDFLIGDLRSVASKLENMVRF
VTEVVDGRLIVTRRRKKELLEELRQRGYAPFPEMRRAARDYDYLLGMRLW
NLTAEMIARLQSQLQKARDELAALEKRTPKDLWAEDLNQLRPRIENLFEE
RAKEIAS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8gcc Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Resolution	2.94 Å
Binding residue (original residue number in PDB)	L464 N465 H518 F631 R639 K640 I826 G827 G829 K876 Y959 H961 T963
Binding residue (residue number reindexed from 1)	L56 N57 H110 F212 R220 K221 I407 G408 G410 K457 Y540 H542 T544

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

PDB	RCSB:8gcc, PDBe:8gcc, PDBj:8gcc
PDBsum	8gcc
PubMed	37384702
UniProt	Q4DE53

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Structure of PDB 8gcc Chain A Binding Site BS01