Structure of PDB 8gbn Chain A Binding Site BS01

Receptor Information

>8gbn Chain A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATP
LAFAHNPSRVWEFYHYRREVMGSKETNAGHRAIAECETRLGKQGRRVVVI
TQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKG
APEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRE
LAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTEFRFHFQGPCGT
TLPEALA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8gbn Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8gbn Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
Resolution	2.7 Å
Binding residue (original residue number in PDB)	C166 C169 C207 C212
Binding residue (residue number reindexed from 1)	C128 C131 C169 C174
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.3.1.-

External links

PDB	RCSB:8gbn, PDBe:8gbn, PDBj:8gbn
PDBsum	8gbn
PubMed	38846003
UniProt	Q9NXA8\|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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