Structure of PDB 8g6r Chain A Binding Site BS01

Receptor Information
>8g6r Chain A (length=899) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTNQTVKPG
HFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYRYNRPTV
LDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLNKFGKAG
LYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTVGGVSLL
STMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLIDGVENPC
LMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCNELAQVL
TEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKLLSVDSN
VCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMILSDDGV
VCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINKGPHEFC
SQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLERYVSLA
IDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLTAKFWDESFYANMYEKS
Ligand information
>8g6r Chain I (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagaagcuauuaaaaucaca
....................
Receptor-Ligand Complex Structure
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PDB8g6r An alphacoronavirus polymerase structure reveals conserved co-factor functions.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S754 D755 C808 S809 R831 K844 R853 S856
Binding residue
(residue number reindexed from 1)		S746 D747 C800 S801 R823 K836 R845 S848
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8g6r, PDBe:8g6r, PDBj:8g6r
PDBsum8g6r
PubMed36993498
UniProtA0A0U2C263

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