BioLiP

Receptor Information

>8g46 Chain A (length=782) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRP
VKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDII
TRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKE
LKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKE
FNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPP
IIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLR
VELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAME
TFTNLGPIVDMCVVDLGQGQLVTCSGAFKEGSLRIIRNGKLHIRTVPLYE
SPRKICYQEVSQCFGVLSSRIEVTTALRPSASTQALSSSVSSSEEVEVHN
LLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRL
YEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEG
NFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQ
HLQEVGLFHLGEFVNVFCHGSLVMQTPTQGSVLFGTVNGMIGLVTSLSES
WYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIES
FLDISRPKMQEVVANLATADDLIKVVEELTRI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8g46 Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	H22 E27 L29 V44 T45 A46 E47 G48 V264 R270 L284 E303 L305 Y316 L317 D318 N319 V321 V338 Y346 M350 E351
Binding residue (residue number reindexed from 1)	H21 E26 L28 V43 T44 A45 E46 G47 V263 R269 L283 E302 L304 Y315 L316 D317 N318 V320 V337 Y345 M349 E350

Enzyme Commision number

	Molecular Function
GO:0003676	nucleic acid binding

	Cellular Component
GO:0005634	nucleus

PDB	RCSB:8g46, PDBe:8g46, PDBj:8g46
PDBsum	8g46
PubMed	36824856
UniProt	Q16531\|DDB1_HUMAN DNA damage-binding protein 1 (Gene Name=DDB1)

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Structure of PDB 8g46 Chain A Binding Site BS01