Structure of PDB 8g1j Chain A Binding Site BS01
Receptor Information
>8g1j Chain A (length=347) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFGNPLSHFL
EGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPE
EISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
Ligand information
>8g1j Chain E (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8g1j
The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R11 L12 K13 R14 H56 E226 K235
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8g1j
,
PDBe:8g1j
,
PDBj:8g1j
PDBsum
8g1j
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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