Structure of PDB 8g10 Chain A Binding Site BS01
Receptor Information
>8g10 Chain A (length=351) Species:
10090
(Mus musculus) [
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TGPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQ
LNTGSYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFGNPLS
HFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIR
NPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVP
KFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLE
QLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFF
LECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
L
Ligand information
>8g10 Chain E (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8g10
The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R14 L15 K16 R17 H59 E230 K239
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8g10
,
PDBe:8g10
,
PDBj:8g10
PDBsum
8g10
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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