Structure of PDB 8fzv Chain A Binding Site BS01

Receptor Information
>8fzv Chain A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSIALPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALL
LLTKEDFRYRSPHSGDELYELLQHILAQARAAFDLYFVLDKSGSVANNWI
EIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLK
RVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAE
KEAKISRSLGASVYAVGVLDFEQAQLERIADSKEQVFPGFQALKGII
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8fzv Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fzv Decreasing the flexibility of the TELSAM-target protein linker and omitting the cleavable fusion tag improves crystal order and diffraction limits.
Resolution3.29 Å
Binding residue
(original residue number in PDB)		S92 S94 T158
Binding residue
(residue number reindexed from 1)		S92 S94 T158
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0043565 sequence-specific DNA binding

View graph for
Molecular Function
External links
PDB RCSB:8fzv, PDBe:8fzv, PDBj:8fzv
PDBsum8fzv
PubMed37747038
UniProtP41212|ETV6_HUMAN Transcription factor ETV6 (Gene Name=ETV6);
P58335|ANTR2_HUMAN Anthrax toxin receptor 2 (Gene Name=ANTXR2)

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