Structure of PDB 8fyh Chain A Binding Site BS01

Receptor Information
>8fyh Chain A (length=514) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHIL
TSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDFINDEIFVELVNALGDKIFEAISSMFEELKEKYKELTEQPPECTPNI
DGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKCNYSFHATPNTYKRK
NTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKPNIEPPENVEWSGAE
ASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIINHVYNYQPC
DHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC
YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAG
WGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDF
VVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELF
FDYRYSQADALKYV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fyh Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fyh Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C528 H530 C539
Binding residue
(residue number reindexed from 1)		C300 H302 C311
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.356: [histone H3]-lysine(27) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
GO:0046976 histone H3K27 methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8fyh, PDBe:8fyh, PDBj:8fyh
PDBsum8fyh
PubMed37733873
UniProtQ15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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