Structure of PDB 8fwp Chain A Binding Site BS01

Receptor Information
>8fwp Chain A (length=269) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQFNIMVVGQSGLGKSTLINTLFASHLIDSATGDDISALPVTKTTEMKIS
THTLVVRLNINVIDTPGFGDFIDNSKAWEPIVKYIKEQHSQYLRKELTAQ
RERFITDTRVHAILYFLQPNGKELSRLDVEALKRLTEIANVIPVIGKSDT
LTLDERTEFRELIQNEFEKYNFKIYPYDSEELTDEELELNRSVRSIIPFA
VVGSENEIEINGETFRGRKTRWSAINVEDINQCDFVYLREFLIRTHLQDL
IETTSYIHYEGFRARQLIA
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain8fwp Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fwp A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly.
Resolution2.22 Å
Binding residue
(original residue number in PDB)		G42 G44 K45 S46 T47 S60 K180 D182 V235 G236 R251
Binding residue
(residue number reindexed from 1)		G12 G14 K15 S16 T17 S30 K147 D149 V202 G203 R218
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8fwp, PDBe:8fwp, PDBj:8fwp
PDBsum8fwp
PubMed37315820
UniProtP25342|CDC10_YEAST Cell division control protein 10 (Gene Name=CDC10)

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