Structure of PDB 8fub Chain A Binding Site BS01

Receptor Information

>8fub Chain A (length=411) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIID

Ligand information

>8fub Chain B (length=11) Species: 928303 (Hendra virus horse/Australia/Hendra/1994) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GKRKKIRTIAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fub Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism.
Resolution	2.75 Å
Binding residue (original residue number in PDB)	S100 F133 W137 N141 S144 G145 T146 T150 Q176 W179 N183 G186 D187 W222 N226
Binding residue (residue number reindexed from 1)	S29 F62 W66 N70 S73 G74 T75 T79 Q105 W108 N112 G115 D116 W151 N155

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fub, PDBe:8fub, PDBj:8fub
PDBsum	8fub
PubMed	37376602
UniProt	O00629\|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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