Structure of PDB 8fty Chain A Binding Site BS01

Receptor Information
>8fty Chain A (length=483) Species: 7111 (Trichoplusia ni) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEKLYPNCDATVWLRSCEEEVSEPLEGTMTGEFPSWLRGTLLRNGPGCLN
VGTMRFEHLFDSSALLHRFAIDDGTVTYQCRFLRTNTLKKNRAANRIVVT
EFGTKSAMSDNAMISVYPFGDEVYAFTEGPIIHRVDTVTLDTLEQKNMTD
CVALVNHTSHPHVMPNGDVYNVGMSVVKGRIRHVVAKFPFTEKGDMFKSA
HIVASMAPRWALHPAYMHTFGITENYFVIVEQPLSISVYGLMTNLINNNK
LAASLKWYPEYETHIVLLSRTTGKEVKRFRTDTLFFLHIINCYEHEGELV
VDLCTYKDAKVVDAMYVHAIETMQSNADYAEWFRAKPKRLQVSLNAPKMT
RMKSSILADIGCETPRIHYDLHNSKYYRYFYAISSDVDAENPGTVIKVDT
KTGETKTWCRPNCYPSEPIFVPSPNAKDEDDGVLLSALVWGGEMNQTVAL
LVLNAKTMEEMGRATFNTPSPAPKCLHGWFLPT
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain8fty Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fty Structure of the carotenoid isomerooxygenase
Resolution1.95 Å
Binding residue
(original residue number in PDB)		H184 H242 H312 H501
Binding residue
(residue number reindexed from 1)		H160 H218 H288 H477
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003834 beta-carotene 15,15'-dioxygenase activity
GO:0010436 carotenoid dioxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0016121 carotene catabolic process
GO:0042574 retinal metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8fty, PDBe:8fty, PDBj:8fty
PDBsum8fty
PubMed38355721
UniProtA0A7E5VY83

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