Structure of PDB 8ftm Chain A Binding Site BS01

Receptor Information

>8ftm Chain A (length=714) Species: 759272 (Thermochaetoides thermophila DSM 1495)

RLIPPMDVLHQAILEWDIFHEGGYRCGNVSDTYPDPYSYKQTFFPLLINE
AWRSFVTAKDETTSKPFGIKVLSRMTVDKFMEVTAAVPAQISKDRGLTEG
DIVIISKGEDPLNQPQELHCLSRIWKTTYKKDTVEVVYRLNAKGNQILPA
LTPGSEFQVVKITNMTTIEREYAALESLQYYDLMDEILKAQPSPMLTFGD
EAIKAVMDNYQLNPGQARAILNAKENDGFTLIQGPPGTGKTKTIVAMVGC
LLTGVLKLLVCAPSNAAVDELVLRLKAGVKTMNGTFHKIEVLRLGRSDVI
NAAVKDVTLDELVKARMDAELRDQLHKEAGEIKAKLAEIRPQLDAARLSD
DRASAMKLQREFDELKRRQAHIGAKIDAGNTYARETEIKRRQIQQEILDK
AQVLCATLSGSGHEMFKNLNVEFETVIIDEAAQCVELSALIPLKYGCNKC
ILVGDPKQLPPTVLSQSAAKYGYDQSLFVRMQKNHPKDVHLLDMQYRMHP
EISRFPSKEFYEGLLQDGADMARLRLQPWHQSVLLGPYRFFDVKGSQERG
PKNQSLVNEEEVKVAMQLYMRFRSDYRDIDLTGKIGIITPYKAQLQRLRQ
KFVERYGESITEQIEFNTTDAFQGRECEIIIFSCVRASPTGGIGFMTDIR
RMNVGLTRARSSLWILGDSRALVQGEFWAKLIEDAKQRDRYTNGNIMALL
SQPGPRVSLESLAK

Ligand information

>8ftm Chain C (length=12)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ftm Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): T1204 N1270 T1273 R1276 P1394 S1395 N1396 G1426 R1427 D1441 S1552 T1605 Q1609 S1698 Y1734 K1735 T1761 D1763 A1764 R1779 G1784 G1785 G1787 F1788
• Binding residue (residue number reindexed from 1): T98 N164 T167 R170 P263 S264 N265 G295 R296 D310 S409 T462 Q466 S555 Y591 K592 T618 D620 A621 R636 G641 G642 G644 F645

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0004386 helicase activity

External links

• PDB: RCSB:8ftm, PDBe:8ftm, PDBj:8ftm
• PDBsum: 8ftm
• PubMed: 37832548
• UniProt: G0S163